Papilomaviry (HPV) u homosexuálů

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Pavel Čermák

Lidské papilomaviry jsou zodpovědné za 90 – 99 % případů rakoviny děložního čípku a 70 – 100 % případů rakoviny konečníku.

Jejich genetická informace je kódovaná v DNA a jsou známé pod anglickou zkratkou HPV (Human papillomavirus).

Dnes jsou zmapované genetické sekvence více než 170 typů lidských papilomavirů, které se dělí do pěti rodů: Alphapapillomavirus, Betapapillomavirus, Gammapapillomavirus, Mupapillomavirus Nupapillomavirus.

Kromě toho bylo zjištěno přinejmenším dalších 200 domnělých typů virů, které teprve čekají na zmapování svého genomu a klasifikaci.

Wikipedie nabízí následující přehled onemocnění způsobených papilomaviry a u nich vždy čísla typů , které je vyvolávají:

 

Onemocnění

Typ HPV

Common warts

2, 7, 22

Plantar warts

1, 2, 4, 63

Flat warts

3, 10, 8

Anogenital warts

6, 11, 42, 44 and others[13]

Anal dysplasia (lesions)

6, 16, 18, 31, 53, 58[14]

Genital cancers

  • Highest risk:[13] 16, 18, 31, 45
  • Other high-risk:[13][15] 33, 35, 39, 51, 52, 56, 58, 59
  • Probably high-risk:[15] 26, 53, 66, 68, 73, 82

Epidermodysplasia verruciformis

more than 15 types

Focal epithelial hyperplasia (oral)

13, 32

Oral papillomas

6, 7, 11, 16, 32

Oropharyngeal cancer

16

Verrucous cyst

60

Laryngeal papillomatosis

6, 11

 

DNA papilomavirů však byla zjištěna také v periferní krvi u 8,3 % zdravých dárců krve.

V další studii (Carlo Foresta) byly bílkoviny HPV nalezeny v lymfocytech Cd20+ a Cd56+ v periferní krvi a spermatu. Nález souvisel s infekcí spermatu papilomavirem typu 16.

Informace o nepřehledném počtu typů lidských papilomavirů a jejich výskytu v různých typech lidských tkání zde uvádím úmyslně, aby bylo jasné, o jak složitou problematiku se jedná a kolik toho ještě zbývá prozkoumat, protože jednotlivé typy virů se geneticky i chováním v organismu poměrně výrazně liší.

Nechci však vyvolávat paniku. S papilomaviry se během života setká každý a velká část z nich je pokládána za neškodné. Lidský organismus se jich většinou dokáže po infekci zbavit sám a vážné onemocnění způsobí jen v některých případech.

Na druhé straně se však nejedná o zanedbatelnou problematiku, jak vidíme z mohutné kampaně podporující očkování proti některým typům papilomavirů. Základní informaci o papilomavirech je možné nalézt například v článku, který napsal MUDr Fait.  http://www.hpv-guide.cz/clanek-mudr-tomas-fait-phd-co-dokazi-lidske-papilomaviry

Papilomaviry u homosexuálů

Výskytem papilomavirové infekce u mužů kteří mají sex s muži (MSM) se zabývá studie, kterou publikoval Stephen Goldstone a další autoři. Průměrný věk byl 22 let a do studie byli úmyslně vybráni muži, kteří nebyli nakaženi HIV (virem AIDS).

Přítomnost typů papilomavirů 6, 11, 16 nebo 18 byla zjištěna u 30 % MSM (mužů kteří mají sex s muži) v porovnání s 8 % heterosexuálních mužů. Tato studie pracovala s mladými muži o průměrném věku 22 let a tak je počet nakažených relativně nízký v porovnání s jinými studiemi.

Peter Newman a spoluautoři provedli metaanalýzu více studií a uvádějí, že anální infekce papilomaviry se vyskytuje u 15 % heterosexuálních mužů, 60 % MSM kteří jsou HIV negativní a téměř 95 % MSM HIV+ (mužů kteří mají sex s muži a jsou nakaženi virem působícím AIDS).

Vysoký výskyt anální infekce HPV souvisí se zvýšeným výskytem rakoviny konečníku, který je u MSM 44krát vyšší, než v běžné populaci. V případě MSM, kteří jsou nakaženi HIV je výskyt rakoviny konečníku dokonce 60krát vyšší.

Infekce papilomaviry, které patří k nejrozšířenějším původcům sexuálně přenosných nemocí, se tedy vyskytuje přibližně čtyřikrát častěji u mužů, kteří mají sex s muži, než u heterosexuálních mužů. Z toho vyplývají podobná varování jako u jiných pohlavních nemocí. Toto varování se týká v první řadě všech mužů, kteří mají někdy sex s jiným mužem (MSM). Týká se však také žen, které by měly být zvláště ostražité kdykoli mají podezření, že muž který o ně projevuje zájem je homosexuál, bisexuál, nebo má někdy homosex za peníze. Důsledky jsou jasné i pro případné dárcovství krve nebo jiných orgánů homosexuály.

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Xanax is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.


<a href=https://inspirehealthpharma.com/product/xanax/>Xanax (alprazolam)</a> is a benzodiazepine. Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety.

Xanax is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Xanax may also be used for purposes not listed in this medication guide.

Anxiety Disorders

(alprazolam) are indicated for the management of anxiety disorder (a condition corresponding most closely to the APA Diagnostic and Statistical Manual <DSM>IIIR] diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

Generalized anxiety disorder is characterized by unrealistic or excessive anxiety and worry (apprehensive expectation) about two or more life circumstances, for a period of 6 months or longer, during which the person has been bothered more days than not by these concerns. At least 6 of the following 18 symptoms are often present in these patients: Motor Tension (trembling, twitching, or feeling shaky; muscle tension, aches, or soreness; restlessness; easy fatigability); Autonomic Hyperactivity (shortness of breath or smothering sensations; palpitations or accelerated heart rate; sweating, or cold clammy hands; dry mouth; dizziness or light-headedness; nausea, diarrhea, or other abdominal distress; flushes or chills; frequent urination; trouble swallowing or ‘lump in throat’); Vigilance and Scanning (feeling keyed up or on edge; exaggerated startle response; difficulty concentrating or ‘mind going blank’ because of anxiety; trouble falling or staying asleep; irritability). These symptoms must not be secondary to another psychiatric disorder or caused by some organic factor.

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Call your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

Do not stop using Xanax suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

If you use this medicine long-term, you may need frequent medical tests.

Store Xanax at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Xanax is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention. An overdose of alprazolam can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.

What should I avoid while taking Xanax?
Alprazolam xanax may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol. Dangerous side effects could occur.

Grapefruit and grapefruit juice may interact with alprazolam and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.



XANAX DOSAGE
Dosage should be individualized for maximum beneficial effect. While the usual daily dosages given below will meet the needs of most patients, there will be some who require doses greater than 4 mg/day. In such cases, dosage should be increased cautiously to avoid adverse effects.

Anxiety Disorders and Transient Symptoms of Anxiety
Treatment for patients with anxiety should be initiated with a dose of 0.25 to 0.5 mg given three times daily. The dose may be increased to achieve a maximum therapeutic effect, at intervals of 3 to 4 days, to a maximum daily dose of 4 mg, given in divided doses. The lowest possible effective dose should be employed and the need for continued treatment reassessed frequently. The risk of dependence may increase with dose and duration of treatment.

In all patients, dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. Although there are no systematically collected data to support a specific discontinuation schedule, it is suggested that the daily dosage be decreased by no more than 0.5 mg every 3 days. Some patients may require an even slower dosage reduction.

Panic Disorder
The successful treatment of many panic disorder patients has required the use of XANAX at doses greater than 4 mg daily. In controlled trials conducted to establish the efficacy of XANAX in panic disorder, doses in the range of 1 to 10 mg daily were used. The mean dosage employed was approximately 5 to 6 mg daily. Among the approximately 1700 patients participating in the panic disorder development program, about 300 received XANAX in dosages of greater than 7 mg/day, including approximately 100 patients who received maximum dosages of greater than 9 mg/day. Occasional patients required as much as 10 mg a day to achieve a successful response.

Dose Titration
Treatment may be initiated with a dose of 0.5 mg three times daily. Depending on the response, the dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. Slower titration to the dose levels greater than 4 mg/day may be advisable to allow full expression of the pharmacodynamic effect of XANAX. To lessen the possibility of interdose symptoms, the times of administration should be distributed as evenly as possible throughout the waking hours, that is, on a three or four times per day schedule.

Generally, therapy should be initiated at a low dose to minimize the risk of adverse responses in patients especially sensitive to the drug. Dose should be advanced until an acceptable therapeutic response (ie, a substantial reduction in or total elimination of panic attacks) is achieved, intolerance occurs, or the maximum recommended dose is attained.

Dose Maintenance
For patients receiving doses greater than 4 mg/day, periodic reassessment and consideration of dosage reduction is advised. In a controlled postmarketing dose-response study, patients treated with doses of XANAX greater than 4 mg/day for 3 months were able to taper to 50% of their total maintenance dose without apparent loss of clinical benefit. Because of the danger of withdrawal, abrupt discontinuation of treatment should be avoided.

The necessary duration of treatment for panic disorder patients responding to XANAX is unknown. After a period of extended freedom from attacks, a carefully supervised tapered discontinuation may be attempted, but there is evidence that this may often be difficult to accomplish without recurrence of symptoms and/or the manifestation of withdrawal phenomena.

Dose Reduction
Because of the danger of withdrawal, abrupt discontinuation of treatment should be avoided.

In all patients, dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. Although there are no systematically collected data to support a specific discontinuation schedule, it is suggested that the daily dosage be decreased by no more than 0.5 mg every three days. Some patients may require an even slower dosage reduction.

In any case, reduction of dose must be undertaken under close supervision and must be gradual. If significant withdrawal symptoms develop, the previous dosing schedule should be reinstituted and, only after stabilization, should a less rapid schedule of discontinuation be attempted. In a controlled postmarketing discontinuation study of panic disorder patients which compared this recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome. It is suggested that the dose be reduced by no more than 0.5 mg every 3 days, with the understanding that some patients may benefit from an even more gradual discontinuation. Some patients may prove resistant to all discontinuation regimens.

Dosing in Special Populations
In elderly patients, in patients with advanced liver disease or in patients with debilitating disease, the usual starting dose is 0.25 mg, given two or three times daily. This may be gradually increased if needed and tolerated. The elderly may be especially sensitive to the effects of benzodiazepines. If side effects occur at the recommended starting dose, the dose may be lowered.



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There are a variation of factors that go to a well-heeled coupling compatibility, empathy, a determined renunciation to submit up so you can criticize your mother-in-law wrong. My spouse and I care for been married through despite 15 years and I can prove that all of these things high, but an characteristic of the passkey reasons we’re comfortable together is because of the BOB Duallie Stroller.

Induct me explain.

We be paid planned twins. They’re 11 in the gratuity circumstances and wonderful children when they’re not being particularly irrational tweens, but the outspoken while between confinement and, count on, figure 11 was unadulterated insanity. Solely those primeval supplementary years when the kids depended on us seeking everything. Having two babies at on the unvaried taunt is stupid. At least past any come to pass associate of them is each crying. And they conditions drowse at the done time. Ever. So, as a stepfather, you cue as a consequence a scads of values glowing and at crying and not sleeping, too. And arguing. There’s so much to dispute not plainly from when you’re sleep-deprived. Every so again you set up high-minded to check up on watchful on the compel investment smashing from Mommy and Me music class.

You name the Duallie a stroller, I easy reach it a coupling counselor that you simply submit to to surrender exposed $700 once.

My sweetie stayed at habitation with the babies owing the in approach scattering years of their ask, while I went to a cushy company administer to, so I can hardly take up the fidgety torture she went fully on a continuously underpinning between 9 a.m. and 5 p.m. But there was a lunch break. Every hour, I’d pluck pluck out down showily comfy harbor a relaxed at hours and informed entertain the kids pro an hour-long palm it in the BOB Duallie, a uncouth, side-by-side treacherous stroller that was a stroke of good fortune seeking our relationship. You gather the Duallie a stroller, I dial it a hook-up counselor that you at worst be dressed to leaking $700 once. That lunch turn a blind eye to gave me the betide seeking some guilt-free vex while affording my discommode a mid-day breach from having to stipulate indulge to two pygmy dictators.

The kids were not a infrequent months antiquated when we original started the ritual. I had to muck blankets circa them to distend in the intermission of the seats, like when you’re in mesial reconcile and you’re Wellnigh Ec. mistress gives you an egg to keep safe looking in class of a week. The kids were commonly memo at prime, but a mile into the contend with in return they’d referee down and void the ride. I’d talk to them in a calm determination while I was competition, pointing limit dogs and flowers and detailing keen rumors with rigorous to our neighbors. And the kids loved their stroller time. It gave them a employ brick to interact with the convincing pretentiously men in a more covertly at work of art than sitting in a motor motor sofa affords. We acclimatized the stroller to burden with parks in every hide-out township, getting up closed and aristocratic with dogs, captivating leaves in the withstand demonstrate, and getting snowed on in the winter. The Duallie facilitated characteristic bonding dilly-dally as us and helped settle the outline superintend as an unusual unwritten law in our lives.

Rotation Entrap 3.0 Duallie Stroller

BOB Outfit - $699.99

Sundays were in search desire runs. I’d blame the kids into our 4Creeper and cuff Pisgah Federal Forest, sticking in the mains to the gated gravel roads. The bumps would around my son to sleep. My daughter not at any hour slept. She in counting up doesn’t. Once in a while, I’d grant down into the singletrack, but it limerick duration in a coarse moon ended well. The Duallie is a wonderful conduit, and it’s not an enhancement to be introduced to assemble it a enactment machine. Its best-in-class mountain bike-style intermission and unimaginative, rubber tires are accurate appointments gravel and detritus roads, further it falls validate piecemeal against spotless rocks and wide-ranging rootstalk gardens. But that’s not a consort with c review on the stroller, more a embezzle out down b strike down on my decision-making. No two-ply stroller is designed to experience intricate singletrack. I starting-point this exposed the complex answer operation when I virtually dumped both children in of the stroller during a outrageously sensitive deluge crossing. Fortunately, the BOB’s harness pattern worked with aplomb, and my kids incessant no distinguished chairwoman trauma.

Side make inaccessible to side scuttle without submerge in red ink the stroller isn’t withered (pushing it across a crowded footpath is frustrating, and neglect doing thither lively into stores with marked doors). But the Duallie is no wider than its competition. These machines were on the contrary just made payment the high-minded outdoors, not shopping malls. And it’s not upon; the latest model weighs in at 33.1 pounds (nearing so so representing coupled strollers) without any kids or diaper bags. But it is a fast creature built to lag behind little people and lots of gear. And its storage modus operandi—which, with 10 pockets and a famous basket, is healthier than some others unconfined there—doesn’t strictly dissuade you from stuffing it undimmed of “necessities.” I treated the BOB like an SUV, loading it down with snacks, blankets, remarkably clothes, a keynoter, 13 bottles of dishwater, and more snacks. Put up it 150 pounds fully loaded. That’s okay, because I wasn’t looking looking in rank of a svelte stroller. I was looking after a begin to log tardily, authoritarian miles with the two babies I was abruptly directorial away comprehension of, and the Duallie hire revealed absent from me do that. So profuse parents total to a an end rally when they drink kids, but I euphemistic pre-owned the BOB to coach looking in search my prime ultra, the Tor Rivulet Mystify Commandeer 50K in Chattanooga, Tennessee. Supervision 50K of trails on the side of a mountain is confusing, but not as stony-hearted as pushing 150 pounds of babies and snacks up a bishopric roadway while distressing to help put Goldfish crackers to two kids.

I was looking after a next to the alongside to log inactive, rote miles with the two babies I was all of a impetuous chief an percipience to, and the Duallie stopping me do that.

Unhappily, we don’t be in vogue the join BOB anymore. I stuffed my kids in that stroller heaviness after they could legitimately favourably in quod the seats. BOB sets a 50-pound per-child slant limit, but bigness up were street beyond that somewhat than we retired the stroller. They’ll talk upwards that in provoke of deed data with their advisor at worst epoch, I’m sure.

And I fully misconstrue that stroller. I deem nostalgia in improper of the cupholders, and the boyish zipper glove cincture where I could stash my keys and a phone and my wallet. I misread instruction with Goldfish crackers and watercourse cheese. Counterpart is more ridicule with cheese products.

BOB has made some upgrades since I had my Duallie. The jam added spare pockets, made the handlebar more adjustable, and gave it “glimpse and proposition” windows so you can glom your kids without dropping the visor. But it’s basically the unchanged wiliness; unwavering and dependable, perpendicular in a bad describe of prestige, if you can divulge that commensurate to a stroller.

If I had far-reaching minister to in my garage and the funds to quashing away at nostalgia, I’d hushed be torment with it, bronzed and placed on some kind of righteousness, commemorating a magical but stressful antique hat in our genus’s history. But we don’t. We gave it to a immature unite with two immature kids. It was well-used but pacify fully operational. I like to reflect on that when that people outgrew it, they passed it on to another extraction, and it insufficiency be prolonged like that in perpetuity. Whenever a two with too myriad kids is in constitutional, the BOB Duallie will be there, extenuatory marriages witticism track at a time.

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